Modulation of Endotoxicity of Shigella Generalized Modules for Membrane Antigens (GMMA) by Genetic Lipid A Modifications
نویسندگان
چکیده
منابع مشابه
Production of a Shigella sonnei Vaccine Based on Generalized Modules for Membrane Antigens (GMMA), 1790GAHB
Recently, we developed a high yield production process for outer membrane particles from genetically modified bacteria, called Generalized Modules of Membrane Antigens (GMMA), and the corresponding simple two step filtration purification, enabling economic manufacture of these particles for use as vaccines. Using a Shigella sonnei strain that was genetically modified to produce penta-acylated l...
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Outer membrane blebs are naturally shed by Gram-negative bacteria and are candidates of interest for vaccines development. Genetic modification of bacteria to induce hyperblebbing greatly increases the yield of blebs, called Generalized Modules for Membrane Antigens (GMMA). The composition of the GMMA from hyperblebbing mutants of Shigella flexneri 2a and Shigella sonnei were quantitatively ana...
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Genetically induced outer membrane particles from Gram-negative bacteria, called Generalized Modules for Membrane Antigens (GMMA), are being investigated as vaccines. Rapid methods are required for estimating the protein content for in-process assays during production. Since GMMA are complex biological structures containing lipid and polysaccharide as well as protein, protein determinations are...
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در این پایان نامه، در ابتدا برای مدول ها روی دامنه های پروفر شرایط معادل به دست آورده ایم و خواصی از ددکیند مدول ها روی دامنه های پروفر مشخص کرده ایم. در ادامه برای ددکیند مدول های با تولید متناهی روی حلقه های به طور صحیح بسته شرایط معادل به دست آورده ایم و ددکیند مدول های ضربی را مشخص کرده ایم. گزاره هایی در مورد بعد ددکیند مدول ها بیان کرده ایم. در پایان، قضایای lying over و going down را برا...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2014
ISSN: 0021-9258
DOI: 10.1074/jbc.m114.566570